Journal of Organic Chemistry p. 8998 - 9006 (2019)
Update date:2022-07-30
Topics:
Liu, Jian-Quan
Chen, Xinyi
Shatskiy, Andrey
K?rk?s, Markus D.
Wang, Xiang-Shan
A silver-mediated reaction between 2-ethynyl-3-(1-hydroxyprop-2-yn-1-yl)phenols or 2-ethynyl-3-(1-hydroxyprop-2-yn-1-yl)anilines and methylene isocyanides has been developed. A sequential 5-endo-dig cyclization and [3 + 2] cycloaddition process is proposed. This synthetic strategy is atom- and step-efficient and applicable to a broad scope of substrates, allowing the synthesis of valuable substituted benzofuran- and indole-pyrroles in moderate to high yields.
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