Synthesis of a novel tetracyclic heterocycle: 1-carboxy-13-oxo-[1,2,3]triazolo [1',5':4,3] [1,4]diazepino [6,7-c]chromane, using salicylaldehyde as a starting material

Article abstract of DOI:10.1016/0040-4020(95)00668-X

A nine-step synthesis of the potentially biologically active title compound, 9, has been achieved starting from salicylaldehyde and involving two 1,3-dipolar cycloaddition reactions and a lactamistion reaction. The cis configuration of compound 9 resulted from that of compound 4 which was confirmed by X-ray crystallography.