Bioorganic and Medicinal Chemistry Letters p. 3217 - 3222 (1998)
Update date:2022-09-26
Topics:
Melero, Concepcion P.
Sevillano, Luis G.
Caballero, Esther
Tome, Fernando
Carron, Rosalia
Montero, Ma Jose
San Feliciano, Arturo
Medarde, Manuel
The synthesis and inotropic activity of two families of hydroindenic compounds are described. Among them, a bis-guanylhydrazone derivative has demonstrated to produce an interesting positive inotropic effect on guinea pig atria, displaying at higher dosis a similar effect to that elicited by digoxin.
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