Interaction of pentafluorobenzoylpyruvic acid and its esters with N-nucleophiles. Synthesis of 4-oxoquinoline-2-carboxylic acids

Article abstract of DOI:10.1016/0022-1139(94)03069-3

Nitrogen-substituted 4-oxoquinoline-2-carboxylic acids have been prepared by the reaction of pentafluorobenzoylpyruvic acid with isopropyl-, cyclohexyl-, phenyl- and ethanol-amine.Ammonia and triethylamine, however, were found to react with pentafluoroben