Ring opening of artemisinin (Qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with formation of N-oxides - A chemical model for antimalarial mode of action

DOI: 10.1016/S0040-4039(99)00830-8

Source and publish data:

Tetrahedron Letters p. 4715 - 4718 (1999)

Update date:2022-08-10

Topics:

Authors:

Haynes, Richard K.

Hendry Hung-On, Pai

Voerste, Arnd

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Article abstract of DOI:10.1016/S0040-4039(99)00830-8

In CH₂Cl₂ in the presence of benzylamine, artemisinin transfers an oxygen atom from the intermediate open hydroperoxide to tertiary amines to form N-oxides and N-benzyl-11-azadesoxyartemisinin. Base-catalyzed side reactions interfere

Full text of DOI:10.1016/S0040-4039(99)00830-8

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