Tetrahedron Asymmetry p. 399 - 408 (1997)
Update date:2022-08-10
Topics:
Goj, Olav
Burchardt, Annegret
Haufe, Guenter
Kinetic resolutions of (+/-)-1-acetoxy-2-fluoro-2-phenylalkanes 1 by enzymatic hydrolysis and of (+/-)-2-fluoro-2-phenylpropanol 2a by lipase-catalyzed acetylation are described for the first time.Hydrolysis of (+/-)-1 with lipase Amano PS (Pseudomonas cepacia) provided both the optically active acetates (-)-1 and the corresponding primary alcohols (-)-2 with high enantiomeric excess. (R)-enantiopreference was observed for the acetylation of (+/-)-2-fluoro-2-phenylpropanol 2a which occurred with higher enantioselectivity and faster conversion compared to the unfluorinated parent compound (+/-)-2-phenylpropanol 3.
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Doi:10.1016/S0040-4039(00)70537-5
(1978)Doi:10.1081/SCC-100103981
(2001)Doi:10.1016/S0040-4039(00)88257-X
(1983)Doi:10.1016/0031-9422(88)84084-6
(1988)Doi:10.1016/S0040-4039(00)01731-7
(2000)Doi:10.14233/ajchem.2019.21955
(2019)