Tetrahedron Letters p. 3651 - 3654 (1995)
Update date:2022-08-17
Topics:
Manoharan, Muthiah
Tivel, Kathleen L.
Cook, P. Dan
Lipophilic nucleosides were synthesized from uridine via either a 2'-O-hexylamino tether or the corresponding 3'-linker.These synthons allowed site-specific incorporation of the lipophilic moieties into antisence oligonucleotides.A spectrum of lipophilicity was observed in the oligonucleotides, depending on the pendent group.
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