Synthesis of 6-aza- and 6-methyl-pyrimidine ribonucleoside phosphoramidites and their incorporation in hammerhead ribozymes

Article abstract of DOI:10.1080/15257779508012497

The synthesis of phosphoramidites of 6-modified pyrimidine ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described.

Full text of DOI:10.1080/15257779508012497

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Nucleosides and Nucleotides
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Synthesis of 6-Aza- & 6-Methyl-
pyrimidine Ribonucleoside
Phosphoramidites and Their
Incorporation in Hammerhead Ribozymes
Leonid Beigelman a , Alexander Karpeisky a & Nassim Usman a
a Department of Chemistry and Biochemistry Ribozyme
Pharmaceuticals Inc. , 2950 Wilderness Place, Boulder, CO, 80301,
USA
Published online: 16 Feb 2007.
To cite this article: Leonid Beigelman , Alexander Karpeisky & Nassim Usman (1995) Synthesis of 6-
Aza- & 6-Methyl-pyrimidine Ribonucleoside Phosphoramidites and Their Incorporation in Hammerhead
Ribozymes, Nucleosides and Nucleotides, 14:3-5, 895-899
To link to this article: http://dx.doi.org/10.1080/15257779508012497
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