Tetrazoles of Manno- and Rhamno-Pyranoses: Inhibition of Glycosidases by Tetrazoles and Other Mannose Mimics

Article abstract of DOI:10.1016/0040-4039(95)01519-1

The synthesis of tetrazoles derived from D-mannopyranose and D-rhamnopyranose from L-gulonolactone is described.These and other materials are assessed as inhibitors of human liver glycosidases and delineate some structural features required for α- and β-mannosidase and α-fucosidase inhibition.