Microbial Transformation of 12-Hydroxyoctadecanoic Acid to 5-n-Hexyl-Tetrahydrofuran-2-Acetic Acid

Article abstract of DOI:10.1007/BF02541090

Stationary-phase cells of a corynebacterium (FUI-2) and a bacillus (NRRL B-14864) isolate, when grown aerobically in 1percent YE medium at 25 deg C, converted 12-hydroxystearic acid to a major compound, 5-n-hexyl-tetrahydrofuran-2-acetic acid, and other intermediate and minor compounds (6-hydroxydodecanoic acid, 4-hydroxydecanoic acid, 4-ketodecanoic acid and γ-decanolactone).The yields of 5-n-hexyl-tetrahydrofuran-2-acetic acid, 4-hydroxydecanoic acid, and γ-decanolactone, by Bacillus lentus NRRL B-14864 were 43percent, 18percent and 5percent, respectively, after 2.5 d of incubation. Key Words: Bacillus lentus, corynebacterium, D-(+)-12-hydroxy-octadecanoic acid, D-(+)-12-hydroxystearic acid, γ-decanolactone, 4-hydroxydecanoic acid, 6-hydroxydodecanoic acid, 4-ketodecanoic acid, 5-n-hexyl-tetrahydrofuran-2-acetic acid.