Journal of Organic Chemistry p. 26 - 28 (1989)
Update date:2022-08-25
Topics:
Moon, Surk-Sik
Stuhmiller, Louise M.
McMorris, Trevor C.
Oogoniol <(24R)-3β,11α,15β,29-tetrahydroxystigmast-5-en-7-one>, a female-activating hormone of Achlya, has been synthesized from 4-androstene-3,11,17-trione.A novel step involved 1,4-addition of the magnesium cyanocuprate derivative of (S)-3-(1-methylethyl)-5-<(tert-butyldimethylsilyl)oxy>pentyl bromide to 3β-hydroxy-15β,16β-epoxy-11-oxo-(17(20)E)-pregna-5,17(20)-diene 3-tert-butyldimethylsilyl ether.Selective hydrogenation of the resulting Δ16 double bond gave only the stigmastene product with the correct stereochemistry at C15, C17, and C20.
View MoreShandong Xinhua Pharmaceutical Co.,Ltd
website:http://www.xhzy.com
Contact:+86-533-2196801
Address:1 lutai road,zhangdian dis,Zibo City
Chengdu Gelipu Biotechnology Co., Ltd.
website:http://www.glp-china.com
Contact:86-28-82610909
Address:chegndu
Rizhao Lanxing Chemical Indusrial Co.,Ltd
Contact:86-633-2616708
Address:NO.15 West road Shenglan, Lanshan district, Rizhao City
Hefei EnliPharma Tecnology Co.,Ltd
Contact:0086-551-66399836
Address:Qing Cheng ShuiXiang Building 805, Mengcheng North Road , ShuangFeng Economic Development Zone Anhui HeFei
Zibo Ocean International Trade Co.,Ltd
Contact:+86 533 5160706
Address:1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China
Doi:10.1021/jo00324a033
(1981)Doi:10.1039/c0nj00722f
(2011)Doi:10.1021/acs.inorgchem.9b03351
(2020)Doi:10.1016/j.cattod.2015.04.008
(2016)Doi:10.1002/adsc.201000266
(2010)Doi:10.1039/c4ra02241f
(2014)