Design, synthesis and antiviral activity of α-L-arabinofuranosyl derivatives of 2-substituted-5,6-dichlorobenzimidazoles

Article abstract of DOI:10.1080/07328319808004326

A number of 2.-s. have been prepared by condensation of 2-bromo-5,6- dichlorobenzimidazole or 2,5,6-trichlorobenzimidazole with tetra-O-acetyl-L- arabinofuranose. 2-Alkylamino derivatives were prepared by a substitution of the 2-chloro group with the appropriate amines. All target compounds were evaluated for activity against HCMV and HSV-1. The 2-chloro and 2-bromo derivatives showed moderate activity against HCMV at non-cytotoxic concentrations.

Full text of DOI:10.1080/07328319808004326

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Design, Synthesis and Antiviral Activity
of α-L-Arabinofuranosyl Derivatives of 2-
Substituted-5,6-dichlorobenzimidazoles
Jean-Luc Girardet a , John C. Drach a , Stanley D. Chamberlain b ,
George W. KosLzalka b & Leroy B. Townsend a
a Department of Medicinal Chemistry, College of Pharmacy,
Department of Chemistry, College of Literature, Sciences and Art,
and Department of Biologic and Materials Sciences , School of
Dentistry, University of Michigan , Ann Arbor, Michigan, 48109-1065
b Glaxo Division of Chemistry , Glaxo Wellcome Co. , Research
Triangle Park, NC, 27709
Published online: 16 Aug 2006.
To cite this article: Jean-Luc Girardet , John C. Drach , Stanley D. Chamberlain , George W.
KosLzalka & Leroy B. Townsend (1998) Design, Synthesis and Antiviral Activity of α-L-Arabinofuranosyl
Derivatives of 2-Substituted-5,6-dichlorobenzimidazoles, Nucleosides and Nucleotides, 17:12,
2389-2401, DOI: 10.1080/07328319808004326
To link to this article: http://dx.doi.org/10.1080/07328319808004326
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