Synthesis and characterization of novel photoreactive naltrexone analogs as isomeric carbene-generating probes for opioid receptors

Article abstract of DOI:10.3987/COM-95-7345

A convenient synthesis of m- and p-CF₃-diazirinylbenzoic acid was developed. A pair of novel photoaffinity probes bearing these diazirines on a naltrexyl framework bind reversibly with high affinity at μ-, δ-, and κ- receptors.