Synthesis of 4,5-disubstituted benzo[c][2,7]naphthyridines by combined metalation-palladium-catalysed cross-coupling strategies. Preparation of 8H-pyrido[4,3,2-mn]acridone as a model of cystodytin alkaloids

Article abstract of DOI:10.1080/00397919608003845

A short and efficient synthesis of 8H-pyrido[4,3,2-mn]acridone is described. The strategy involves the preparation of 4-chloro-5-methylbenzo[c][2,7]naphthyridine, as key intermediate, by metalation and Palladium catalyzed cross-coupling reaction. A second cross-coupling reaction and subsequent oxidation by SeO₂ led to the title compound.

Full text of DOI:10.1080/00397919608003845

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Synthetic Communications: An
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Synthesis of 4,5-Disubstituted
Benzo[c][2,7]naphthyridines
by Combined Metalation-
Palladium-Catalysed
Cross-Coupling Strategies.
Preparation of 8h-Pyrido[4,3,2-
mn]acridone as a Model of
Cystodytin Alkaloids
F. Guillier a , F. Nivoliers a , C. Cochennec a , A.
Godard a , F. Marsais a & G. Quéguiner a
a Laboratoire de Chimie Organique Fine et
Hétérocyclique de l'IRCOF associé au CNRS, INSA
de Rouen, BP08, 76131 Mont-Saint-Aignan Cedex,
France
Published online: 23 Aug 2006.
To cite this article: F. Guillier , F. Nivoliers , C. Cochennec , A. Godard , F. Marsais
& G. Quguiner (1996) Synthesis of 4,5-Disubstituted Benzo[c][2,7]naphthyridines by
Combined Metalation-Palladium-Catalysed Cross-Coupling Strategies. Preparation
of 8h-Pyrido[4,3,2-mn]acridone as a Model of Cystodytin Alkaloids, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 26:23, 4421-4436
To link to this article: http://dx.doi.org/10.1080/00397919608003845

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