Preparation of carbon-14 labeled organophosphate pesticides: Chlorfenvinphos

Article abstract of DOI:10.1002/(SICI)1099-1344(199804)41:4<261::AID-JLCR77>3.0.CO;2-5

Synthesis of [vinyl-¹⁴C]chlorfenvinphos, utilizing [¹⁴C]iodomethane as the source of the label, was accomplished in 28% radiochemical yield by the methylation of 2,4-dichlorobenzoyl chloride, chlorination of the resulting [¹⁴C]-2,4-dichloroacetophenone, and condensation of the product with triethylphosphite. The product, isolated as a mixture of E and Z isomere (3.6 and 96.3%, respectively), was obtained in >99% purity and had specific activity 20 mCl/mmol.