Synthesis of bis(carbamoyl ester) derivatives of D-glucose as antifungal products

Article abstract of DOI:10.1080/07328309708005735

Regiospecific carbamoylation of di-O-isopropylidene protected D-glucose gave a series of carbamoyl, thiocarbamoyl and dithiocarbamoyl esters at the C-3 secondary site. These were partially and fully deprotected to give two series of derivatives such that a choice of the extent of hydrophilic character could be made. The partially protected products were further derivatized regioselectively with a second carbamoyl, thiocarbamoyl or dithiocarbamoyl group at the C-6 primary site. We also report on antifungal properties of some of those compounds.

Full text of DOI:10.1080/07328309708005735

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Journal of Carbohydrate Chemistry
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Synthesis of Bis(Carbamoyl Ester)
Derivatives of D-Glucose as Antifungal
Products
Christophe Len a , Denis Postel a , Gino Ronco a & Pierre Villa a
a Laboratoire de Chimie Organique et Cinetique, Université de
Picardie-Jules Verne , 33 rue Saint Leu, 80039, Amiens, France
Published online: 23 Aug 2006.
To cite this article: Christophe Len , Denis Postel , Gino Ronco & Pierre Villa (1997) Synthesis of
Bis(Carbamoyl Ester) Derivatives of D-Glucose as Antifungal Products, Journal of Carbohydrate
Chemistry, 16:7, 1029-1049, DOI: 10.1080/07328309708005735
To link to this article: http://dx.doi.org/10.1080/07328309708005735
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