Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin

Article abstract of DOI:10.1016/S0960-894X(99)00192-4

Reaction of C-(1-bromo-1-deoxy-β-D-glucopyranosyl)formamide 2 with thiocyanate ions was the key step of a short synthesis of D- glucopyranosylidene-spiro-thiohydantoin 7 which proved to be a potent inhibitor of muscle and liver glycogen phosphorylases.