Journal of Medicinal Chemistry p. 4259 - 4263 (1992)
Update date:2022-08-11
Topics:
Jiang, Jack B.
Johnson, Mary George
Defauw, Jean M.
Beine, Tracey M.
Ballas, Lawrence M.
et al.
A novel series od diaminoanthraquinones was discovered initially as protein kinase C inhibitors with IC50s in the 50-100 μM range.They exhibited potent tumor cell growth inhibitory activity in vitro without cross resistance to adriamycin.Further evaluation of two of the most active compounds NSC 639365 (3) and NSC 639366 (4) in human tumor cloning assay showed potent cytocidal activity.The results suggest therapeutical potentials against human tumors.
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