A concise procedure for the preparation of enantiopure 3-alkylpiperidines

DOI: 10.1016/S0957-4166(97)00204-8

Source and publish data:

Tetrahedron Asymmetry p. 2237 - 2240 (1997)

Update date:2022-08-17

Topics:

Authors:

Amat, Mercedes

Llor, Nuria

Hidalgo, Jose

Bosch, Joan

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Article abstract of DOI:10.1016/S0957-4166(97)00204-8

Reaction of (R)-phenylglycinol with racemic methyl 4-formylhexanoate takes place with a remarkable stereoselectivity to give two diastereomeric 6-ethyloxazolopiperidones (9:1 ratio) in 76% overall yield. After LiAlH₄ reduction and catalytic hyd

Full text of DOI:10.1016/S0957-4166(97)00204-8

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