Metabolites of Microorganisms. Sulfur-Containing Ansa Compounds of the Naphthomycin Type

Article abstract of DOI:10.1002/hlca.19860690610

From a strain of Streptomyces (Tue 2357) in addition to naphthomycin A, 4 new yellow pigments were isolated and their structures determined by spectroscopic comparison with naphthomycin A.Whereas the naphthomycins D and E are simple derivatives of naphthomycin A, having OH and H, respectively, instead of Cl, the naphthomycins F and G contain an N-acetylcysteine residue linked to the aromatic moiety by a thioether group.Degradations with O3 yielded identical products from the naphthomycins A, D, F, and G, showing coincident configurations in parts of the molecules.Naphthomycin F shows some biological activity against gram-positive bacteria and fungi, although much weaker than naphthomycin A.The naphthomycins D, E, and G are inactive against microorganisms.