Synthesis of 2-amino-5-(1-methyl-5-nitro-[4-3H]-2-imidazolyl)-1,3,4- thiadiazole

Article abstract of DOI:10.1002/(SICI)1099-1344(199801)41:1<47::AID-JLCR52>3.0.CO;2-C

2-Amino-5-(1-methyl-5-nitro-4-iodo-2-imidazoyl)-1,3,4-thiadiazole (5) was prepared from imidazole via a 4-steps sequence. Reductive desiodination of 5 using a tetrahydrofuran solution of NaBH₄ in the presence of tritiated water provided the title compound (specific radioactivity 12.6 Ci/mmol) in one step.