Synthese et proprietes antibacteriennes et antifongiques d'une serie de 1-alkylimidazoles

Article abstract of DOI:10.1016/0223-5234(90)90009-R

A homologous series of 1-alkylimidazoles (pentyl to octadecyl) has been obtained with a good yield (75-95percent) by the phase transfer catalyzed reaction of imidazole with the appropriate alkyl halides.The antifungal and antibacterial activities of these compounds were tested.A poor activity was observed towards the Gram-negative (Gram-) microorganisms, whereas the aerobic and anaerobic Gram-positive (Gram+) microorganisms and some yeasts (Pityrosporum ovale) were inhibited.We found that the inhibitory potency of such compounds increased with increasing chain length,passing through a maximum with chain length C10-C13 and decreased for the higher homologs.An explanation is suggested in relation to the ability of these compounds to bind with the active sites of the microorganisms and to adopt a conformation able to promote the migration through the biological membranes.