Bioorganic and Medicinal Chemistry Letters p. 2469 - 2472 (1997)
Update date:2022-08-11
Topics:
Du, Shoucheng
Tsipori, Hana
Baasov, Timor
The new amino phosphonate 4, which mimics the ionic and steric properties of putative oxocarbenium intermediate 3, was synthesized from D-mannose and evaluated as inhibitor of Kdo8P synthase. it was found that 4 is the most potent inhibitor of the enzyme yet tested, with a K(i) value of 3.3 μM.
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