
Organic Process Research and Development p. 922 - 923 (2007)
Update date:2022-08-11
Topics:
Madhra, Mukesh K.
Sharma, Mukesh
Khanduri
A short and practical method for the synthesis of 1-amino-3,5-dimethyl- adamantane (Memantine hydrochloride) was established by using tertiary butyl alcohol under Ritter conditions to give 1-acetamido-3,5-dimethyl-adamantane. The 1-acetamido-3,5-dimethyl-adamantane is hydrolyzed using alkali to give free base which was then converted into its hydrochloride acid.
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