NEW METHODOLOGY IN DETERMINING EVIDENCE FOR SINGLE ELECTRON TRANSFER IN THE REACTION OF GRIGNARD REAGENTS WITH KETONES

Article abstract of DOI:10.1016/0022-328X(85)87318-6

A new method is reported to determine the existence of single electron transfer in the reaction of Grignard reagents with ketones.The method involves the determination of pseudo-first order rate constants by following the rate of disappearance of the paramagnetic intermediate and relating the rate of this disappearance to the appearance of the product.The reactions of methyl-, phenyl- and t-butyl-Grignard reagents with substituted benzophenones were examined.This method should be applicable to a wide range of organometallic reactions.