Synthesis of 11,13-bridged progestational steroids

DOI: 10.1016/S0960-894X(97)10113-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2925 - 2928 (1997)

Update date:2022-08-15

Topics:

Authors:

Broess Broess

Groen Groen

Hamersma

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Article abstract of DOI:10.1016/S0960-894X(97)10113-5

11,13-Ethanopregnanes were prepared to assess the influence of the bending of the steroid skeleton on progestagenic activity. It was demonstrated that, contrary to previous assumptions, upward bending of the A ring has little overall effect on the activity.

Full text of DOI:10.1016/S0960-894X(97)10113-5

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