A general route to N'-(2,2-difluoro-3-hydroxyalkanoyl)nornicotines

DOI: 10.1016/0022-1139(95)03268-I

Source and publish data:

Journal of Fluorine Chemistry p. 171 - 176 (1995)

Update date:2022-08-16

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Authors:

Fukuda, Hiroshi

Kitazume, Tomoya

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Article abstract of DOI:10.1016/0022-1139(95)03268-I

The preparation of a variety of N'-(2,2-difluoro-3-hydroxyalkanoyl)nornicotines via a Reformatsky-type reaction of ethyl bromodifluoroacetate with aldehydes is described.The difluoromethylene unit may be regarded as an isopolar and isosteric replacement f

Full text of DOI:10.1016/0022-1139(95)03268-I

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