
Journal of Fluorine Chemistry p. 171 - 176 (1995)
Update date:2022-08-16
Topics:
Fukuda, Hiroshi
Kitazume, Tomoya
The preparation of a variety of N'-(2,2-difluoro-3-hydroxyalkanoyl)nornicotines via a Reformatsky-type reaction of ethyl bromodifluoroacetate with aldehydes is described.The difluoromethylene unit may be regarded as an isopolar and isosteric replacement f
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