Synthesis of 4-benzidinyl butyric acid: A key intermediate for antibodies production against benzidin

Article abstract of DOI:10.1080/00397919808003065

A four-step synthesis of monoalkylated benzidin is reported for immunogen preparation against benzidin dye. Use of 10% H₂SO₄/dioxan for N- Boc cleavage avoids the cyclisation of 4-benzidinyl butyric acid into the corresponding lactam

Full text of DOI:10.1080/00397919808003065

Synthetic Communications
ISSN: 0039-7911 (Print) 1532-2432 (Online) Journal homepage: http://www.tandfonline.com/loi/lsyc20
Synthesis of 4-Benzidinyl Butyric Acid: A Key
Intermediate for Antibodies Production Against
Benzidin
Nathalie Fischer-Durand , Samy Ben Rejeb & François Le Goffic
To cite this article: Nathalie Fischer-Durand , Samy Ben Rejeb & François Le Goffic (1998)
Synthesis of 4-Benzidinyl Butyric Acid: A Key Intermediate for Antibodies Production Against
Benzidin, Synthetic Communications, 28:6, 963-970, DOI: 10.1080/00397919808003065
To link to this article: http://dx.doi.org/10.1080/00397919808003065
Published online: 20 Aug 2006.
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Date: 13 October 2015, At: 21:15