Tetrahedron Letters p. 4473 - 4476 (1998)
Update date:2022-08-12
Topics:
El-ghayoury, Abdelkrim
Ziessel, Raymond
Pyridine and oligopyridines bearing halide or triflate groups react smoothly with CO (1 atm) and n-butanol in the presence of a tertiary amine and a catalytic amount of bis(triphenylphosphine)palladium dichloride to afford the corresponding esters. When ethanol and a disubstituted substrate are used under milder conditions, selective mono-carboalkoxylation occurs. Amidation is effected using a primary amine as nucleophile.
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