DIASTEREOSELECTIVE SYNTHESIS OF (E)-ALKENES AND (E)-1,ω-DIENES STARTING FROM DIASTEREOISOMERIC MIXTURES OF l-BROMO-l-ALKENES : NEW SYNTHESES OF MONOUNSATURATED OR BRIDGED RING-KETAL NATURALLY OCCURRING SUBSTANCES.

Article abstract of DOI:10.1016/S0040-4039(00)84576-1

The PdCl2(dppf)-catalyzed cross-coupling reaction between diastereoisomeric mixtures of l-bromo-l-alkenes which contain n equiv. of (E)-stereoiomers and n equiv. of Grignard reagents allows to obtain (E)-alkenes or (E)-l,ω-dienes having 95.5-99percent stereoisomeric purity in satisfactory yields.Such compounds are useful precursors to several naturally occurring substances.