Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the multipin(TM) support

Article abstract of DOI:10.1016/S0040-4039(99)00426-8

A new and simple linker has been developed for synthesis of secondary amides and sulfonamides. This application is based on the reductive amination reaction between the acetophenone subunit of the linker and a wide range of primary amines including aliphatic and aromatic amines. Cleavage is effected under mild acidic conditions (20% TFA/DCM) to release the products in good yield and purity.