Organic Mass Spectrometry p. 552 - 558 (1993)
Update date:2022-08-16
Topics:
Cushnir, J. R.
Naylor, S.
Lamb, J. H.
Farmer, P. B.
Human exposure to carcinogenic alkylating agents can lead to the formation of covalently bound adducts in DNA, some of which are excreted in urine as alkylated purines following DNA degradation and repair.Tandem mass spectrometric methods have been developed for the qualitative and quantitative determination of such alkylpurines in human urine.Short-chain alkyl- and hydroxyalkylguanines have been synthesized with the substituents at the N-7, O6- and N2-positions of guanine.Examination of the product ion scans of their molecular ions (electron impact (EI) ionization) revealed that the ion at m/z 151,
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