Synthesis of (+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid through lipase-catalyzed asymmetric acetylation

DOI: 10.1246/cl.1999.405

Source and publish data:

Chemistry Letters p. 405 - 406 (1999)

Update date:2022-07-30

Topics:

Authors:

Kirihara, Masayuki

Takuwa, Tomofumi

Kawasaki, Masashi

Kakuda, Hiroko

Hirokami, Shun-Ichi

Takahata, Hiroki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/cl.1999.405

(+)-(R)-1-Amino-2,2-difluorocyclopropane-1-carboxylic acid was synthesized via the lipase-catalyzed asymmetric acetylation of a pro-chiral diol as the key step.

Full text of DOI:10.1246/cl.1999.405

Products guided by the article

Product name:1-tert-butoxycarbonylamino-2,2-difluoro-cyclopropanecarboxylic acid

Cas No:228580-13-0

R&D Labs maybe for 228580-13-0

Shanghai Sungo Technology Chemical Co., Ltd

Contact:0086-21-51385579

Address:Room2010, F/20, Tonghua Plaza, NO 345 Jinxiang Road, Jinqiao Export Processing Zone, Shanghai, 201206 P.R.CHINA
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Zhuhai Rundu Pharmaceutical co.,Ltd

Contact:+86-756-7630755

Address:No.6,North Airport Road,Sanzao Town,Jinwan District
GenicBio Limited

Contact:+86-(0)21-3770 9035

Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China

Relevant to this article

Doi:10.1021/ja01065a022
(1964)
Doi:10.1021/jo00830a046
(1970)
Doi:10.1021/ja01044a061
(1969)
Doi:10.1021/jo00830a118
(1970)
Maximization of the energy capability level in transition metal complexes through application of 1-amino- and 2-amino-5: H -tetrazole ligands

Doi:10.1039/c8ta06326e
(2018)
Propagation of polar substituent effects in 1-(substituted phenyl)-6,7-dimethoxy-3,4-dihydro- and -1,2,3,4-tetrahydroisoquinolines as explained by resonance polarization concept

Doi:10.1021/jo0507946
(2005)

Article Doi