Synthesis of novel 2-seleno-1,8-naphthyridines derivatives

Article abstract of DOI:10.1080/10426500701839601

Synthesis of series of new 2-phenyl-3-(2-seleno-1,8-naphthyridin-3-yl)-2,3, 3a,6-tetrahydro-5H-pyrazolo[3,4-d][1,3]thiazol-5-ones (4a-e) has been reported. The replacement of halogen with NaHSe in the substituted 2-chloro-3-formyl-1,8- naphthyridi afforded 2-seleno-3-formyl-1,8-naphthyridins (2a - e). The reaction between (2a-e) and 1,3-thiazolidine-2,4-dione produced corresponding derivatives of substituted compounds (3a-e), which on reflux with phenyl hydrazine in DMF to generate (4a-e), with good to excellent yields. Structure of newly synthesized compounds were established based on elemental analysis, IR, 1H NMR, and mass spectral data. Copyright Taylor & Francis Group, LLC.