Kinetic Resolution of Racemic Allylic Alcohols by BINAP-Ruthenium(II)-Catalyzed Hydrogenation

DOI: 10.1021/jo00238a048

Source and publish data:

Journal of Organic Chemistry p. 708 - 710 (1988)

Update date:2022-08-10

Topics:

Authors:

Kitamura, Masato

Kasahara, Isamu

Manabe, Kenji

Noyori, Ryoji

Takaya, Hidemasa

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Article abstract of DOI:10.1021/jo00238a048

Chiral allylic secondary alcohols have been resolved efficiently by homogeneous hydrogenation catalyzed by (R)- or (S)-BINAP-Ru diacetate complex.The combined effects of intramolecular and intermolecular asymmetric induction give up to 76:1 differentiation between the enantiomeric unsaturated alcohols.

Full text of DOI:10.1021/jo00238a048

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