A novel route to pyrimidine isodideoxynucleosides via michael-type addition on unsaturated modified sugars

Article abstract of DOI:10.1080/00397919708003388

A short, stereocontrolled synthesis of isonucleosides is described. This approach is based on the Michael-Type addition of silylated uracil or thymine with an appropriate acceptor as pyranoside precursor. The alkylated products obtained allow carbonyl reduction, providing a straightforward way to prepare new sugar-modified nucleosides.

Full text of DOI:10.1080/00397919708003388

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Novel Route to Pyrimidine
Isodideoxynucleosides via
Michael-Type Addition on
Unsaturated Modified Sugars
Natacha Prévost a & Francis Rouessac a
a Laboratoire de Synthèse Organique, associé au
CNRS, Faculté des Sciences Université du Maine ,
Avenue O. Messiaen, F-72017, Le Mans cedex E-mail:
Published online: 22 Aug 2006.
To cite this article: Natacha Prévost & Francis Rouessac (1997) A Novel Route to
Pyrimidine Isodideoxynucleosides via Michael-Type Addition on Unsaturated Modified
Sugars, Synthetic Communications: An International Journal for Rapid Communication
of Synthetic Organic Chemistry, 27:13, 2325-2335, DOI: 10.1080/00397919708003388
To link to this article: http://dx.doi.org/10.1080/00397919708003388
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