Use of Montmorillonite clay for the synthesis of linear tetrapyrroles and their cyclization to uroporphyrinogens

Article abstract of DOI:10.1016/S0040-4039(00)60710-4

Linear tetrapyrroles, such as the formylbilane (1), were obtained by condensation of α-hydroxymethyldipyrromethanes with α-free dipyrromethanes using Montmorillonite clay as acid catalyst. After reduction of the formyl group, hydroxymethylbilanes were cyc