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ChemComm
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COMMUNICATION
Journal Name
D. Bonne and J. Rodriguez, J. Am. Chem. Soc., 2017, 139
Chem., Int. Ed., 2019, 58, 1494–1498; (DeO) SI:.-1C0..1Z0h39e/nDg0,CQC.0W54a3n2Ag
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,
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Scheme 6 Derivatization of the chiral products
In summary, we have developed an efficient method for
chiral phosphoric acid-catalyzed asymmetric synthesis of
arylindolyl indolin-3-ones with an axial chirality and
a
quaternary stereocenter chirality via reaction of 3-arylindoles
with 2-aryl-3H-indol-3-ones, and the target products were
obtained in high yields with excellent enantioselectivity and
diastereoselectivity. The present method not only provides a
new kind of axially and centrally chiral arylindolyl indolin-3-one
backbones, but also affords an organocatalytic protocol for the
simultaneous construction of both axial and central chirality in
a molecule.
The authors would like to thank Dr. Mrs Haifang Li in our
department for her great help in high resolution mass
spectrometric analysis, the National Natural Science
Foundation of China (Grant No. 21772108) and National Key
R&D Program of China (2016YFD0201207) for financial support.
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Conflicts of interest
There are no conflicts to declare
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Notes and references
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4 | J. Name., 2012, 00, 1-3
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