ANTIFUNGAL ACTIVITY OF PISIFERIC ACID DERIVATIVES AGAINST THE RICE BLAST FUNGUS

Article abstract of DOI:10.1016/S0031-9422(00)82465-6

Twenty-eight derivatives of pisiferic acid (1), an antifungal constituent of Chamaecyparis pisifera var. plumosa against Pyricularia oryzae, were prepared and tested for activity.The size of the substituents at C-10 and C-12, as well as the presence and electronegativity of the constituent oxygen atoms, were inferred to be structural determinants for the activity of pisiferic acid derivatives.A computer graphic comparison between the derivates and probenazole (35) (a commercial antifungal agent of the fungus) revealed the similarity of the size and location of the oxigen-containing substituents, which was supported by the similar mode of action of 1 and 35.Key Word Index - Chamaecyparis pisifera var. plumosa; Cupressaceae; antifungal activity; structure-activity; computer graphic; pisiferic acid; probenazole.