Journal of Fluorine Chemistry p. 99 - 106 (1982)
Update date:2022-08-22
Topics:
Wakselman, C.
Tordeux, M.
Trifluoroethyl cyclohexyl ketone (4) is prepared by acylation of difluoroethylene (2) with cyclohexanecarboxylic acid chloride (1), followed by Cl->F exchange with potassium fluoride in the presence of triethylbenzylammonium chloride.Bayer-Villinger oxidation of ketone (4) with trifluoroperacetic acid gives cyclohexyl trifluoropropionate (5). 3,3,3-trifluoropropionic acid (6) is obtained by treatment of (5) with trimethylsilyl iodide.Condensation of 2,2,2-trifluorodiazoethane (7) with ethyl glyoxylate (8) gives mainly ethyl 4,4,4-trifluoro-2-ketobutyric acid ester (9) which leads after hydrolysis to the corresponding acid (12).
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