Synthesis and reactions of 4-tributylstannyl-3-methylisoxazole

Article abstract of DOI:10.3987/com-96-7489

1,3-Dipolar cycloaddition reaction of bis(tributylstannyl)acetylene with nitrile oxides, followed by treatment with aqueous ammonia in ethanol in a sealed tube gave 4-tributylstannyl-3-methylisoxazole. The palladium catalyzed cross coupling reaction of the isoxazole with 2-iodonitrobenzene, followed by reductive cyclization afforded 3-acetylindole.