Journal of Pharmaceutical Sciences p. 318 - 321 (1988)
Update date:2022-08-11
Topics:
Carstensen
Attarchi
In a previous study, we showed that aspirin in the presence of limited amounts of moisture falls to follow Leeson-Mattocks kinetics at 62.5 degrees C. This system has been tested at a series of temperatures, and several plausible models have been tested. It is shown that the data are explained by a model in which the reaction is limited to a surface interaction between aspirin and water from the sorbed bulk moisture layer.
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