Chemical Biology and Drug Design p. 764 - 777 (2017)
Update date:2022-08-16
Topics:
Saeed, Aamer
Larik, Fayaz Ali
Channar, Pervaiz Ali
Mehfooz, Haroon
Ashraf, Mohammad Haseeb
Abbas, Qamar
Hassan, Mubashir
Seo, Sung-Yum
In this study, some new azomethine-triazole hybrids 5a–5l derived from N-benzoyl-L-phenylalanine were synthesized and characterized. The synthesized compounds showed first-rate, urease inhibition, and compounds 5c and 5e were found to be most effective inhibitors with 0.0137?±?0.00082?μm and 0.0183?±?0.00068?μm, respectively (thiourea 15.151?±?1.27?μm). The kinetic mechanism of urease inhibition revealed the compounds 5c and 5e to be non-competitive inhibitors, whereas compounds 5d and 5j were found to be of mixed-type inhibitors. Docking studies also indicated better interaction patterns with urease enzyme. The results of enzyme inhibition, kinetic mechanism and molecular docking suggest that these compounds can serve as lead compounds in the design of more effective urease inhibitors.
View MoreTianjin Bright Future Technology Co., Ltd
Contact:0086-22-58016666
Address:NO.136 DongTeng Lake Street Tianjin Economic and Technology Development Area,Tainjin,China
Contact:+86-0512-69209969
Address:Room 317,Lushan Road,Suzhou New District,Jiangsu Province,China.
Contact:+86-29-88710656
Address:South Tai bai Road, High Tech Development Zone, Xi'an China
Shangyu Sanhechemicals Co.,LTD.
Contact:86-0571-56696839
Address:Num.2952,Nanhuan Road,Binjiang District,Hangzhou,China
Lanzhou huibang biological chemical technology Co., LTD
Contact:0931-7843964
Address:NO.2011,Yannan Road,Chengguan,
Doi:10.1039/a807020b
(1999)Doi:10.1016/j.bmcl.2011.08.115
(2011)Doi:10.1002/zaac.201600047
(2016)Doi:10.14233/ajchem.2015.19346
(2015)Doi:10.1002/hlca.19880710545
(1988)Doi:10.1039/DT9920001893
(1992)