1,4-Diaminobutanes from furans: A new synthetic approach to substituted putrescines

Article abstract of DOI:10.1016/S0040-4039(98)00903-4

A novel approach for the synthesis of (hydroxymethyl)- and (aminomethyl)-putrescines starting with furanmethanols and aminomethyl- furanmethanols is reported. The furans were converted to their 2,5-dimethoxy- tetrahydrofuran derivatives and the latter were ring-opened in acid media. The resulting carbonyl derivatives were isolated as their dioximes and the latter were then reduced to the corresponding amino alcohols.