Synthesis of 2-(2-hydroxyaroylmethylene)hexahydropyrimidines from 2-trichloromethylchromones and trimethylenediamine

Article abstract of DOI:10.1007/BF02494859

The reactions of 2-trichloromethylchromones with trimethylenediamine in ethanol at room temperature afford 2-(2-hydroxyaroylmethylene)hexahydropyrimidines. Under analogous conditions, 2-methylchromone gives a mixture of N,N′-trimethylenebis[3-amino-1-(2′-hydroxyphenyl)-2-buten-1-one] and N,N′-trimethylenebis(imine) of 2-hydroxyacetophenone.