Bioorganic and Medicinal Chemistry Letters p. 3429 - 3434 (1999)
Update date:2022-08-29
Topics:
Honda, Tadashi
Rounds, BarbieAnn V.
Bore, Lothar
Favaloro Jr., Frank G.
Gribble, Gordon W.
Suh, Nanjoo
Wang, Yongping
Sporn, Michael B.
Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed similar high inhibitory activity (IC50 = 0.8 nM) to 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), which we have synthesized previously, against production of nitric oxide induced by interferon-γ in mouse macrophages.
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(1970)
