Enantioselective hydrogenation of dehydro-amino acid derivatives using pindophos-rhodium as chiral catalyst

Article abstract of DOI:10.1016/0957-4166(96)00105-X

The enantiomers of PINDOPHOS, the aminophosphine phosphinite derivative of the commercial β-blocker Pindolol, were prepared and used as ligands in the rhodium catalyzed asymmetric hydrogenation of non-proteinogenic amino acid precursors. The isolated (R)- and (S)-configured rhodium complexes are highly active catalysts leading to (L)- or (D)-amino acids. Enantiomeric excesses between 92 and 95% ee could be realized. The newly obtained amino acid derivatives were fully characterized by NMR spectroscopy.