Synthesis and Tritium Labelling of 6β-Amino-4,5α-epoxymorphinans and Their 14-Hydroxy Derivatives as Potential Affinity Labelling Probes with μ Opioid Agonist Activity

Article abstract of DOI:10.1002/hlca.19960790114

The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described.The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b,c,e,f) as well as in tritiated form (3b,c,e,f).