Synthesis of difluorocyclopropyl carbocyclic homo-nucleosides

DOI: 10.1016/S0040-4020(98)00324-X

Source and publish data:

Tetrahedron p. 6445 - 6456 (1998)

Update date:2022-08-29

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Authors:

Csuk, Rene

Eversmann, Leo

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Article abstract of DOI:10.1016/S0040-4020(98)00324-X

Racemic difluorinated carbocyclic homo-nucleoside analogues are easily accessible from (Z)-4-(benzyloxy)-2-butenyl acetate by difluorocyclopropanation using sodium chlorodifluoro acetate in diglyme at 190°C followed by Mitsunobu reactions.

Full text of DOI:10.1016/S0040-4020(98)00324-X

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