A FACILE SYNTHESIS OF 3,4-HOMOADAMANTANEDIOL VIA THE REACTION OF 1-ADAMANTYL TRIFLATE WITH CARBON MONOXIDE

Article abstract of DOI:10.1016/S0040-4039(00)89173-X

The reaction of 1-adamantyl triflate (1) with carbon monoxide and adamantane catalyzed by triflic acid affords 3-hydroxy-4-homoadamantyl 1-adamantanecarboxylate (2) as a major product, which is easily converted to 3,4-homoadamantanediol (5) - a promising starting material for 3,4-bifunctional homoadamantane derivatives.